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Our group is interested in the studying correlation of structure with self-assembling properties of 4(R/S)-(OH/NH2)-substituted prolyl polypeptides and collagen mimetics. Another area of interest is to enhance cell permeability Peptide Nucleic Acid (PNA) through cationic and fluorinated analogues towards potential application as antisense therapeutic agents and modulate their molecular recognition features through novel Janus PNA… Continue reading Prolyl Polypeptides and Peptide Nucleic Acids (Prof K N Ganesh)
Month: August 2022
Plant Signaling Group (Swarup Roy Choudhury)
We are interested in identifying the molecular and cellular mechanisms behind signal transduction in plants to unravel plant signaling pathways extending from receptors to signaling cascades and target genes that are crucial to root nodule development, plant architecture determination and stress adaptation. The important questions are: How signaling is initiated by receptor-like kinases and which… Continue reading Plant Signaling Group (Swarup Roy Choudhury)
Genomics and Systems Biology group (Sreenivas Chavali)
Our research aims at obtaining a holistic understanding of how variation in information flow affects phenotypes and fitness. We particularly focus on understanding how sequence variation- single nucleotide changes, repeats or compositional bias within intrinsically disordered proteins/regions influence the function(s), regulation and evolution of biomolecules, with special emphasis on health and disease. To address this,… Continue reading Genomics and Systems Biology group (Sreenivas Chavali)
Single Molecule Biophysics Lab (Nibedita)
Our research focuses on amalgamating DNA nanotechnology and biomolecule in its native form to answer basic questions that are pertinent to the field of Biophysics. In particular we are interested in designing reconfigurable DNA structures responsive to external stimuli and its potential application in therapeutics. We are also interested in exploring the mechanism of biomolecule… Continue reading Single Molecule Biophysics Lab (Nibedita)
Plant Stress Biology group (Annapurna Devi Allu)
Our research focuses on understanding the transcriptional and epigenetic regulation of plant growth and stress responses. We are particularly interested in studying the effect of priming on plant response to individual and combined environmental stresses. The molecular mechanisms that determine the duration of primed state and stress memory in plants will be investigated.
Ash Lab (Ashwani Sharma)
Ash Lab works in the area of nucleic acid aptamers, which are single stranded DNA or RNA oligonucleotides having high affinity and specificity to their target. Aptamer binding to its target is utilized in designing new biosensing platforms for disease detection and diagnostics. In addition, the lab also focuses on construction of DNA/RNA based nanoparticles… Continue reading Ash Lab (Ashwani Sharma)
Cellular and Vascular Biology Lab (Sanjay Kumar)
Our lab research focuses on signaling mechanisms that define the complex responses to TGF-β in the mammalian system. We also study the role of mitochondrial proteins in normal cellular functions and human diseases.
Neuroscience Lab (Vasudharani Devanathan)
Our group is focused on the following areas of research: Cell adhesion molecules (CAMs) in regulating neurogenesis, neurite outgrowth and degeneration; specific interactions among CAMs and their downstream signalling mechanisms. Molecular mechanisms of neuronal dysfunction in diabetic retinopathy. G-protein signalling in platelets and neutrophils.
Cellular and Molecular Parasitology (Suchi Goel)
Our research focuses on pathogenesis of severe malaria parasite where adhesion of parasites in the microvasculature leads to activation of stress signalling pathways in human host.
Molecular Oncology and Cell Signalling (Pakala Suresh Babu)
Our group works on understanding the molecular mechanisms of coregulators in signal transduction, Gene regulation, inflammation, Cancer progression and Cancer metastasis. Our research interests also include developing transgenic and knock out mouse models for studying the role of coregulator signalling in cancer and inflammatory disorders.
