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Our research focuses on amalgamating DNA nanotechnology and biomolecule in its native form to answer basic questions that are pertinent to the field of Biophysics. In particular we are interested in designing reconfigurable DNA structures responsive to external stimuli and its potential application in therapeutics. We are also interested in exploring the mechanism of biomolecule induced conformational transitions of higher order DNA junctions and structures using single molecule techniques such as Total Internal Reflection Fluorescence Microscopy, Fluorescence Correlation Spectroscopy, multi-parameter photon time-stamping spectroscopy etc.