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Home  »  Mr. Birendra Nayak

Birendra Nayak

Academic Background


I have completed my Bachelor’s degree in chemistry from Banki Autonomous college (Utkal University), Cuttack in 2018 and Masters in Chemistry from Pondicherry University in 2020. I joined as project assistant under the guidance of Dr Kiran Kumar Pulukuri at IISER from 2021 Aug -2022 Aug. I enrolled in PhD at IISER Tirupati in 2022 Aug in the same lab.

Courses taken

  • CHM 623: – Organometallic Chemistry
  • CHM 622: – Organic Synthesis -1
  • CHM714; – Transition Metal Chemistry
  • CHM 713: – Bioinorganic Chemistry

Internal Teaching Assistantship

  • CHM 221 – General Organic Chemistry.
  • CHM 212 – Chemistry Lab II.

External Teaching Assistantship

I am teaching Coordination Chemistry and Organometallic chemistry at Visodaya Degree College, Venkatagiri, Andhra Pradesh.


  • Joint CSIR-UGC JRF in chemical Science in 2021 June with AIR -100.
  • Qualified Gate 2022 in chemistry.

Research Interest


Over the past three decades, the importance of antifungal medications in modern medicine has significantly increased. This rise can be attributed to the elevated risk that serves fungal infection pose to individual with weakened immune system. However, it is surprising that only one new class of antifungal drug has been developed during this period. Moreover, there is a growing emergence of infections caused by mold species that lacks effective medical treatments. Consequently, there is an urgent demand for the developing new drugs with innovative molecular structures and novel mechanism of action to combat drug resistant fungal infections. Bilobalide although a less potent PAF antagonist than the ginkgolides, Bilobalide, the major single component in G. biloba extracts, exerts several biological effects not associated with the other terpene trilactones. Bilobalide has shown to supress hypoxia-induced membrane breakdown in the brain, via the potent inhibition of phospholipase 2 activity (EC50 0.38µM). Bilobalide has also been reported to inhibit hypoxia-induced decrease of ATP levels in endothelial cells. The leaves of G. Biloba are well known for their insect resistance to many insects. It has been shown that bilobalide is much more toxic to insects than are the ginkgolides and is comparable to synthetic insecticides, with low mammalian toxicity (LD50 > 500mg/kg in mice) and no mutagenicity of phytotoxicity. Therefore, for my doctoral thesis, I propose to focus on the synthesis of Ilicicolin H (1), its analogues, to discover new antifungal agents and the total synthesis of neuroprotective agent Bilobalide.


Advisor Information

Dr Kiran Kumar Pulukuri, Assistant Professor at Dept. of Chemistry IISER Tirupati is a passionate synthetic chemist. He is an enthusiastic scientific personal who works both on Complex total synthesis as well as challenging method developments. He is also an extraordinary teacher in the laboratory as well as in the classroom. He obtained his PhD from Dept. of chemistry at JNU, India (work carried out at IICT and CDRI) in 2013 under the guidance of Prof. T.K. Chakraborty. Then he moved to Rice University, Houston, USA for his post- doctoral research under the supervision of Prof. K.C. Nicolau from 2013-2019. In Dec 2019, he joined IISER Tirupati as an Assistant Professor in Chemistry.