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Research Interests
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- Development of novel strategies utilizing nucleic acid based nanoparticles for targeted drug delivery to different cancers.
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- In vitro selection of target specific DNA/RNA aptamers using SELEX and their application in diagnostics as well as therapeutics.
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- DNA/RNA based biosensors for detection of small molecules.
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- Target-dependent nucleic acid based molecular devices.
Educational and Professional Career
- PhD (2011): National Chemical Laboratory (NCL), Pune, Maharashtra, India
- Postdoctoral Fellow (2011 – 2013): University of Utah, Salt Lake City, USA
- Postdoctoral Fellow (2013 – 2015): Markey Cancer Centre, University of Kentucky, Lexington, USA
- DST Young Scientist (2016-2017): Indian Institute of Chemical Technology (IICT), Hyderabad, India
- Assistant Professor(January, 2017 ~): Indian Institute of Science Education and Research (IISER) Tirupati, India
Honors and Awards
- Young Scientist (Start-up grant) from SERB, DST, Govt. of India
Selected Publications
- Sharma, A.; Haque, F; Fengmei, P.; Shalyakhtenko, L. S.; Evers, B. M.; Guo, P. Controlled self-assembly of RNA dendrimers. Nanomedicine, 2016, 3, 835
- Lee, T.; Yagati, A. K.; Pi, F.; Sharma, A.K. ; Choi, J.-W.; Guo, P., Construction of RNA Quantum Dot Chimera for Nanoscale Resistive Biomemory Application. ACS Nano 2015, 9, 6675.
- Sharma, A. K. ; Plant, J. J.; Rangel, A. E.; Meek, K. N.; Anamisis, A. J.; Hollien, J.; Heemstra, J. M. Fluorescent RNA Labeling Using Self-Alkylating Ribozymes. ACS Chem. Biol. 2014, 9, 1680.
- Sharma, A. K. ; Kent, A. D.; Heemstra, J. M. Enzyme-Linked Small-Molecule Detection using Split Aptamer Ligation. Anal. Chem. 2012, 84, 6104.
- Sharma, A. K. ; Heemstra, J. M. Small Molecule-Dependent Split Aptamer Ligation. J. Am. Chem. Soc. 2011, 133, 12426.
Teaching
- CHM-221: Organic Chemistry
- CHM-314: Separation Science and Technology
Open Positions
We are constantly looking forward for applications from highly motivated young researchers. Interested candidates should directly contact by email at a.sharma@iisertirupati.ac.in
