English
Hindi
Telugu
Date & Time: 4th April (Thursday), 5:00 p.m. to 6:00 p.m.
Venue: UG lab Lecture Hall at Permanent Campus
Speaker: Prof Shekhar C. Mande, PhD, FNA, FNASc, FASc
Honorary Distinguished Faculty
Bioinformatics Centre, Savitribai Phule Pune University, Pune
Title of the talk: Electron transfer and free radical transfer mechanisms in ribonucleotide reductase complex of M. tuberculosis.
Abstract:
Our laboratory has been involved in developing a structural understanding of electron transfer mechanisms and free radical transfer mechanisms in M. tuberculosis. Over the last several years, we have determined the structures of many enzymes in these pathways. The two pathways converge on a very important enzyme complex, the ribonucleotide reductase. This enzyme complex catalyse the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. X-ray crystallographic and CryoEM structures of multiple components in this enzyme complex enhance our understanding of the complex reaction to a large extent. I will present the recent advances in this direction.
About the speaker:
Prof Shekhar C. Mande is a structural and computational Biologist. He received a Ph.D. in Molecular Biophysics from the Indian Institute of Science, Bangalore (1991). He had postdoctoral training at the Rijksuniversiteit Groningen, Groningen, Netherlands and the University of Washington, Seattle, USA. He worked as Scientist C at the Institute of Microbial Technology, Chandigarh, from 2001 to 2006 and as a Staff Scientist at the Centre for DNA Fingerprinting and Diagnostics, CDFD, Hyderabad, from 2006 to 2010. His research interests include protein structure and function, the biology of Mycobacterium tuberculosis, probed through structural analysis of proteins by various biophysical and biochemical approaches, applications of graph theory to large-scale protein interaction networks, and computational methods to analyse large-scale biological data. He was the Director General of the Council of Scientific and Industrial Research (CSIR), India, and the Secretary of the Department of Scientific and Industrial Research (DSIR), Ministry of Science and Technology. Prior to this, he was the Director of the National Centre for Cell Science, Pune, from 2011 to 2018. He received multiple prestigious awards including B M Birla Young Scientist Award, 1999; Shanti Swarup Bhatnagar Prize for Biological Sciences, 2005; Bharat Asmita Tantravigyan Puraskar 2019; Honorary D.Sc. degree (honoris causa) 2019 by Amity University, Noida. He is also the recipient of the Wellcome Trust International Senior Research Fellow. He is a fellow of all three science academies in India, including the National Academy of Sciences, Allahabad; the Indian National Science Academy, Delhi; and the Indian Academy of Sciences, Bangalore.
