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Faculty Details

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  • Dr. Vasudharani Devanathan

Dr. Vasudharani Devanathan

Associate Professor & Chair, Biology

vasudharani@iisertirupati.ac.in

+91  (877) 250 0403

Group page Link

Research Interests

  • Our lab investigates the long-term impact of metabolism on neuronal structure and function, with a focus on hyperglycemia-induced changes. By uncovering the mechanisms driving diabetes-related neurodegeneration in the brain and eye, we aim to bridge fundamental research with clinical applications. Through collaborations with clinicians in Tirupati, we are advancing translational projects on Traumatic Brain Injury, Glioblastoma, and the role of altered glycemic conditions in brain disorder recovery. Our work paves the way for novel therapeutic insights into metabolic influences on neural health.

Newer research interest (in collaboration with external institutes/industry)

  • STEM education and research in newer teaching methods in interdisciplinary biology teaching.

Educational and Professional Career

  • Ph.D (04, 2008): Centre for molecular neuroscience, University of Hamburg, Germany
  • Postdoctoral scientist (04, 2008 – 05, 2010): Institute for biochemistry and molecular biology, University of Duesseldorf and Institute for pharmacology and toxicology, University of Tuebingen, Germany
  • Senior scientist (05, 2010 – 05, 2012): Institute for pharmacology and toxicology, University of Tuebingen, Germany
  • Visiting faculty/Teaching faculty (01, 2013 – current and 01, 2015 – 08, 2015): The Institute of mathematical sciences and The Maharaja Sayajirao University of Baroda
  • Assistant Professor (August, 2015 ~): Indian Institute of Science Education and Research (IISER) Tirupati, India

Honors and Awards

    • Recipient of DBT-BIRAC (2024) – Grand challenges India – Women Leadership in STEM program.
    • Recipient of Fulbright (2023) Nehru Academic Professional Excellence Award
    • DST women’s scientist award (KIRAN SoRF), 2015 from Department of science and technology, India
    • PhD fellowship for selected overseas students, Hamburg medical school, 2006 from Universitaets Klinikum Eppendorf, Hamburg, Germany
    • Team award for Hit evaluation in antimycobacterial project, 2002 from Astra Zeneca India, Bangalore

Selected Publications

  • Devanathan V, Hagedorn I, Kahler D, Pexa K, Cherpokova D, Kraft P, Singh M, Rosenberger P, Stoll G, Birnbaumer L, Piekorz RP, Beer-Hammer S, Nieswandt B, Nuernberg B. “Platelet Gi protein Gai2 is an essential mediator of thrombo-inflammatory organ damage in mice”, Proc. Natl. Acad. Sci. U S A 119(20), 6491-6 (2015).
  • Kahler D, Devanathan V, Bernardo de Oliveira Franz C, Eldh T, Novakovic A, Roth JM, Granja T, Birnbaumer L, Rosenberger P, Beer-Hammer S, Nuernberg B, “Gai2- and Gai3-deficient mice display opposite severity of myocardial ischemia reperfusion injury”, PLoS One 9(5) , e98325 (2015).
  • Kanig K, Marth L, Roissant J, Granja T, Jennewein C, Devanathan V, Schneider M, Koehler D, Zarbock A, Rosenberger P., “The plexin C1 receptor promotes acute inflammation.”, Eur J Immunol 44(9) , 2648-58 (2014).
  • Busse K, Strotmann R, Strecker K, Wegner F, Devanathan V, Gohla A, Schoeneberg T, Schwarz J., “Adaptive gene regulation in the Striatum of RGS9-deficient mice.”, PLoS One 9(3) , e92605 (2014).
  • Siraskar B, Huang DY, Pakladok T, Siraskar G, Sopjani M, Alesutan I, Kucherenko Y, Almilaji A, Devanathan V, Shumilina E, Foeller M, Munoz C, Lang F“Downregulation of the renal outer medullary K(+) channel ROMK by the AMP-activated protein kinase”, Pflugers Arch 465(2) , 233-45 (2013).
  • Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth.
    Devanathan V, Jakovcevski I, Santuccione A, Li S, Lee HJ, Peles E, Leshchyns’ka I, Sytnyk V, Schachner M. J Neurosci. 2010 Jul 7;30(27):9292-305. doi: 10.1523/JNEUROSCI.5657-09.2010.

Teaching

  • Bio 111: Introductory Biology I: Basic Principles
  • Bio 112: Biology Lab I: Basic Biology
  • Bio 121: Introductory Biology II: Cellular and Molecular Biology
  • Bio 122: Biology Lab II: Biochemistry, Genetics & Molecular Biology
  • Bio 212: Introductory Biology IV: Biology of Systems

Outreach:

    • My outreach has been in the form of science writing. Have contributed to science magazines in their editorial, journal club and other columns.
  • Labtimes
      -Germany based english lab magazine.
  • Science reporter (CSIR journal)
      – reaches various schools in India.
For updated publications:

 

For lab news follows:
X-@LabVasudha

Open Positions

Will be updated soon.

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