Chemistry Archives | Page 33 of 57

Aza-PNA: Engineering E-Rotamer selectivity directed by intramolecular H-bonding.

Shiraj, A., Ramabhadran, R. O., & Ganesh, K. N. (2022). Aza-PNA: Engineering E-Rotamer selectivity directed by intramolecular H-bonding. Organic Letters, 24(40), 7421-7427. DOI: 10.1021/acs.orglett.2c02993

Gemdimethyl Peptide Nucleic Acids (α/β/γ-gdm-PNA): E/Z-rotamers influence the selectivity in the formation of parallel/antiparallel gdm-PNA:DNA/RNA duplexes

Kulkarni, P., Datta, D., & Ganesh, K. N. (2022). Gemdimethyl Peptide Nucleic Acids (α/β/γ-gdm-PNA): E/Z-rotamers influence the selectivity in the formation of parallel/antiparallel gdm-PNA:DNA/RNA duplexes. ACS Omega, 7(44), 40558-40568. DOI: 10.1021/acsomega.2c05873

400 MHz NMR: Bruker AVANCE NEO 400 MHz FT-NMR Spectrometer (ordered)

Multipurpose Broad Band Smart probe designed for X-nuclei observation with 1H decoupling and 1H observation. Range: 19F, 31P-109Ag. Autosampler with 60 samples. Accessories for Reaction monitoring.

Fluorescence Spectrometer: JASCO FP-8500

Analyses the fluorescence of a sample with applications in biochemical, medical, and chemical areas. Time resolved fluorescence measurement. Temperature range from -10 °C to 100°C

FT-IR: Bruker ALPHA

Used for functional group analysis of compounds. Easier FTIR sampling method that is ideal for both solids and liquids. ZnSe-ATR crystal for the analysis of powders, solids, pastes and liquids.

CD Spectrometer: Jasco J1500

Used for protein conformational studies. Quantitative analysis of pharmaceuticals. Testing the optically purity of active substances. Automated CD measurement up to 192 samples. Stopped- flow system that can measure both CD and Fluorescence.

Analytical HPLC: Shimadzu LC 20 AD

Analysis, Identification, and quantification of compounds. Quaternary pump with PDA detector. With an automatic pulsation-correction mechanism & high-speed micro plunger drive, it achieves pulse-free solvent delivery.