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Home  »  PMR FELLOWSHIP REPORT Pooja Yadav

WRITE-UP FOR PMR FELLOWSHIP JUN 2021 - DEC 2021

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Pooja Yadav

WRITE-UP FOR PMR FELLOWSHIP JUN 2021 - DEC 2021

Academic Progress

  1. Courses Done during PhD
    • Physical Organic Chemistry
    • Transition metal Chemistry
    • Organic Synthesis I
    • Organic Synthesis I
  2. Teaching Assistantships       CHM 221- Organic chemistry in Second and Fourth semester
  3. Open Seminar
    • Title: Continuous Flow Chemistry in Organic Synthesis- Recent Trends
    • Date: 18/02/21
  4. Comprehensive Examination 
    • Date: 7/04/21
  5. RAC-1
    • Date: 30/08/2021
    • First RAC presentation involved 2 Chapters.

 

Chapter 1

ortho- C-H functionalization of Aniline derivatives via Dual Electro-Organic Synthesis

Chapter 2

Multicomponent Reaction via Dual Photoredox catalysis

Thesis Objective

Aniline and its derivatives play a major role in pharmaceutical industries due to the presence of this core in various drugs like sulfanilamide, dapsone, procainamide etc. Hence functionalization of aniline and its derivatives could give access to several new structures with potential biological applications.

Simple C-H Functionalization of aniline and its derivatives via Electro-Organic Synthesis

Simple ortho C-H functionalization of aniline derivatives using a transition metal catalyst via electro-organic synthesis is currently attempted with various functional groups such as aryl, trifluromethyl, acyl etc.  

Scheme 1: Functionalization of aniline and its derivatives

Functionalization of aniline and its derivatives via sequential addition coupling reactions using dual metallaphotoredox catalysis – Accessing highly functionalized aniline derivatives.

Different transition metal catalysts and photocatalysts such as Ru(bpy)3Cl2, Eosin Y etc. will be screened together with the additives and solvents to find the optimized reaction conditions using aniline or other aryl substrates as standard for the construction of a highly functionalized aniline derivative including heterocycles. If successful the methodology will be extended to different aniline derivatives and with different olefin partners and functional groups to demonstrate the versatility of the methodology.

Scheme 2: Reaction of anilines with olefins and other functional derivatives.

Publication

1. Aryl Diazonium Salts in Photoredox Catalysis – Recent Trends.

Sakamuri Sarath Babu, P. Muthuraja, Pooja Yadav and Purushothaman Gopinath.* Adv. Synth. Catal. 2021, 363, 1782-1809.