WRITE-UP FOR PMR FELLOWSHIP FROM AUG 2020 – FEB 2021

Reshma Babu

WRITE-UP FOR PMR FELLOWSHIP FROM AUG 2020 – FEB 2021

Courses done during PhD

Physical Organic Chemistry
Bio-inorganic Chemistry
Transition-Metal chemistry
Organic Synthesis 1

Teaching assistantships

CHM 122 – Chemistry Laboratory 1
CHM 211 –Inorganic Chemistry

Objectives of my thesis

Chapter 1.

**Nickel-Catalyzed β-Alkylation of Secondary Alcohols with Primary Alcohols via Borrowing Hydrogen Strategy**

We have studied a catalytic cross-coupling of primary and secondary alcohols via borrowing hydrogen strategy under nickel catalysis. This method provides an atom-economical method for β-alkylation of secondary alcohols under mild, benign conditions. Interestingly the β-alkylation of cholesterol derivative and double β-alkylation of cyclopentanol with various alcohols were also demonstrated.

Chapter 2.

Manganese Catalyzed Direct Catalytic Symmetrical, Unsymmetrical N,N-Dialkylation and Cyclization of Acylhydrazides Using Alcohols.

Our Mn-catalytic protocol provides a one-pot synthesis of both symmetrical and unsymmetrical N,N-disubstitutedacylhydrazides using alcohols. Interestingly, the use of diols resulted in the intermolecular cyclization of acylhydrazides and such products are more relevant in biologically active compounds.

Publications

J. Rana, R. Babu, M. Subaramanianand E. Balaraman*, Ni-catalyzeddehydrogenative coupling of primary and secondary alcohols with methyl-N-heteroaromatics, Org. Chem. Front., 2018, 5, 3250–3255.
V. Landge, R. Babu, V. Yadav, M. Subramanian, Gupta, V, and E. Balaraman*, Iron-Catalyzed Direct Julia-type Olefination of Alcohols, J. Org, Chem., 2020, 85, 9876−9886.