Sreenivas Chavali


Associate Professor

Department of Biology, IISER Tirupati


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Research Interests

  • Natural and disease-associated genetic variation
  • Repeats and Low-complexity sequences
  • Intrinsically Disordered Proteins/Regions
  • Gene-expression Regulation
  • Phase separation
  • Molecular interactions


Educational and Professional qualifications

  • Ph.D (2009): University of Pune; Work done at CSIR-Institute of Genomics and Integrative Biology, Delhi, India
  • Post-doctoral Fellow (February 2009- October 2010): University of Gothenburg, Gothenburg, Sweden
  • Career Development Fellow (November 2010- January 2012): MRC Laboratory of Molecular Biology, Cambridge, UK
  • EMBO Long Term Fellow (February 2012- January 2014): MRC Laboratory of Molecular Biology, Cambridge, UK
  • Investigator Scientist (February 2014- December 2018): MRC Laboratory of Molecular Biology, Cambridge, UK
  • Assistant Professor (January, 2019 ~): Indian Institute of Science Education and Research (IISER) Tirupati, India


Honors and Fellowships

  • UK-Medical Research Council (MRC), End of the year Special Award Scheme award for outstanding scientific contributions in 2017 (Awarded in February 2018)
  • The European Network– NGP-NET COST action’s Short-term Scientific Mission fellowship to undertake a sabbatical at Institute for Molecular and Cell Biology, Portugal, 2018
  • Research Fellowship, Wolfson College, University of Cambridge (2015-2018)
  • Associate Faculty member, F1000 prime in the field of Genomics & Genetics (2015-2016)
  • MRC Special Award Scheme Lite award for contribution to public outreach during Cambridge Science Festival, 2015
  • FEBS Young Scientists’ Forum Fellowship, 2013
  • Indian National Science Academy Young Scientist Medal, 2012
  • European Molecular Biology Organization (EMBO)- Long Term Fellowship (2012-2014)
  • Elected member of Educational Policy Committee, Wolfson College, University of Cambridge (2012-2016)
  • Junior Research Fellowship, Wolfson College, University of Cambridge (2012-2015)
  • Council of Scientific and Industrial Research, Government of India, Junior and Senior Research Fellowships to pursue Ph.D. studies (2002-2007)


Selected publications

  1. Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM. Pharmacogenomics of GPCR Drug Targets. Cell. 2018;172: 41-54.
  2. Chavali S*, Chavali PL, Chalancon G, de Groot NS, Gemayel R, Latysheva NS, Ing-Simmons E, Verstrepen KJ, Balaji S, Babu MM. Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins. Nature Structural & Molecular Biology. 2017; 24: 765-777. (*Co-corresponding author)
  3. Gemayel R, Chavali S, Pougach K, Legendre M, Zhu B, Boeynaems S, van der Zande E, Gevaert K, Rousseau F, Schymkowitz J, Babu MM, Verstrepen KJ. Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity. Molecular Cell. 2015; 59: 615-627.
  4. Barrenäs F, Chavali S, Alves AC, Coin L, Jarvelin MR, Jörnsten R, Langston MA, Ramasamy A, Rogers G, Wang H, Benson M. Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms. Genome Biology. 2012; 13: R46. (Joint First Author)
  5. Chavali PL, Funa K, Chavali S*. Cis-regulation of microRNA expression by scaffold/matrix-attachment regions. Nucleic Acids Research. 2011; 39: 6908-6918. (*Corresponding author)

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