Sreenivas Chavali

Associate Professor
Department of Biology, IISER Tirupati
Email: schavali@iisertirupati.ac.in
Research Interests
- Natural and disease-associated genetic variation
- Repeats and Low-complexity sequences
- Intrinsically Disordered Proteins/Regions
- Gene-expression Regulation
- Phase separation
- Molecular interactions
Educational and Professional qualifications
- Ph.D (2009): University of Pune; Work done at CSIR-Institute of Genomics and Integrative Biology, Delhi, India
- Post-doctoral Fellow (February 2009- October 2010): University of Gothenburg, Gothenburg, Sweden
- Career Development Fellow (November 2010- January 2012): MRC Laboratory of Molecular Biology, Cambridge, UK
- EMBO Long Term Fellow (February 2012- January 2014): MRC Laboratory of Molecular Biology, Cambridge, UK
- Investigator Scientist (February 2014- December 2018): MRC Laboratory of Molecular Biology, Cambridge, UK
- Assistant Professor (January, 2019 ~): Indian Institute of Science Education and Research (IISER) Tirupati, India
Honors and Fellowships
- UK-Medical Research Council (MRC), End of the year Special Award Scheme award for outstanding scientific contributions in 2017 (Awarded in February 2018)
- The European Network– NGP-NET COST action’s Short-term Scientific Mission fellowship to undertake a sabbatical at Institute for Molecular and Cell Biology, Portugal, 2018
- Research Fellowship, Wolfson College, University of Cambridge (2015-2018)
- Associate Faculty member, F1000 prime in the field of Genomics & Genetics (2015-2016)
- MRC Special Award Scheme Lite award for contribution to public outreach during Cambridge Science Festival, 2015
- FEBS Young Scientists’ Forum Fellowship, 2013
- Indian National Science Academy Young Scientist Medal, 2012
- European Molecular Biology Organization (EMBO)- Long Term Fellowship (2012-2014)
- Elected member of Educational Policy Committee, Wolfson College, University of Cambridge (2012-2016)
- Junior Research Fellowship, Wolfson College, University of Cambridge (2012-2015)
- Council of Scientific and Industrial Research, Government of India, Junior and Senior Research Fellowships to pursue Ph.D. studies (2002-2007)
Selected publications
- Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM. Pharmacogenomics of GPCR Drug Targets. Cell. 2018;172: 41-54.
- Chavali S*, Chavali PL, Chalancon G, de Groot NS, Gemayel R, Latysheva NS, Ing-Simmons E, Verstrepen KJ, Balaji S, Babu MM. Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins. Nature Structural & Molecular Biology. 2017; 24: 765-777. (*Co-corresponding author)
- Gemayel R, Chavali S, Pougach K, Legendre M, Zhu B, Boeynaems S, van der Zande E, Gevaert K, Rousseau F, Schymkowitz J, Babu MM, Verstrepen KJ. Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity. Molecular Cell. 2015; 59: 615-627.
- Barrenäs F†, Chavali S†, Alves AC, Coin L, Jarvelin MR, Jörnsten R, Langston MA, Ramasamy A, Rogers G, Wang H, Benson M. Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms. Genome Biology. 2012; 13: R46. (†Joint First Author)
- Chavali PL, Funa K, Chavali S*. Cis-regulation of microRNA expression by scaffold/matrix-attachment regions. Nucleic Acids Research. 2011; 39: 6908-6918. (*Corresponding author)