SUCHI GOEL

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Assistant Professor

Department of Biology, IISER Tirupati

Email: suchi@iisertirupati.ac.in

Phone: +91 877 2500 447

Group Webpage

Research Interests

Infectious disease biology, Molecular and Cellular biology of malaria parasite, Sequestration of malaria parasite and it's role in severe pathogenesis of malaria.

Educational and Professional Career

  • Ph.D (2000- 2006): International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi

  • Post-doctoral Fellow (2006 - 2007): The Ohio State University, USA.

  • Post-doctoral Fellow (2007 - 2011): Pennsylvania State University, USA.

  • Assistant Professor (2012 - 2016): Karolinska Institutet, Sweden.

  • Infosys Fellow (2016 - 2017): Indian Institute of Scinces (IISc), Bangalore, India.

  • Assistant Professor (2017 ~): Indian Institute of Science Education and Research (IISER) Tirupati, India

Honours and Awards

Selected Publications

  • Wahlgren M, Goel S, Akhouri RR., " Multi-gene families of Plasmodium falciparum and the pathogenesis of severe malaria. ", Nature Reviews Microbiology June 12 , (2017) doi: 10.1038/nrmicro.2017.47.

  • Akhouri RR, Goel S, Furusho H, Skoglund U, Wahlgren M " Architecture of human IgM in complex with P.falciparum erythrocyte membrane protein 1. " , Cell Reports 14(4) 723-36 (2016)

  • Goel S, Palmkvist M, Moll K, Joannin N, Lara P, Akhouri RR, Moradi N, Ojemalm K, Angeletti D, Westman, M, Hulth AK, Olsson ML, Eriksson H, Lehtio J, Blixt O, Idestrom L, Gahmberg CG, Storry JR, Heijne GV, Nilsson I, Wahlgren ., " RIFINs are adhesins implicated in severe Plasmodium falciparum malaria ", Nature Medicine 21 (4), 314 - 317 (2015).
    News and Views Manco-Silvia L, Mota MM (2015). A mediator for malaria stickiness in A versus O blood. Nat. med. 21(4): 314-317.

  • Goel S*, Muthusamy A, Miao J, Cui L, Salanti A, Winzeler EA, Gowda DC., " Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity. ", J Biol. Chem. 289(49) , 34408-21(2014) (*co-corresponding author).

  • Goel S, Valiyaveetil M, Achur RN, Goyal A., Mattei D, Salanti A, Trenholme KR, Gardiner DL and Gowda DC, " Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins. ", Proc. Natl. Acad. Sci. USA 107 (38), 16643-8 (2010).

  • Achur RN*, Kakizaki I*, Goel S*, Kojima K, Madhunapantula SV, Goyal A, Ohta M, Kumar S, Takagaki K and Gowda DC. Structural interactions in chondroitin 4-sulfate mediated adherence of Plasmodium falciparum infected erythrocytes in human placenta during pregnancy associated malaria. ", Biochemistry 47, 12635-43 (2008).(* equal first author)

Teaching

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