Prof. K N Ganesh



Krishna N Ganesh
Professor and Coordinator, Chemistry
Director, IISER Tirupati
J C Bose Fellow (DST), NCL Pune

E-mail: director at iisertirupati.ac.in
              kn.ganesh at iisertirupati.ac.in

Website: http://www.iisertirupati.ac.in/institute/director/knganesh.php

 
OFFICE :
              Indian Institute of Science Education and Research,
              Main Building, Ground Floor,
              Karakambadi Road, Tirupati,
              Andhra Pradesh 517507, India

K N Ganesh

Education and previous work experience

     1967-1972 B.Sc and M.Sc (Bangalore University)
     1972-1977, Ph.D (Delhi University)
     1977-1980, Ph.D (Cambridge University, UK)
     1981-1987, Scientist, Centre for Cellular and Molecular Biology, Hyderabad
     1987-2006, Scientist, National Chemical Laboratory, Pune
     1994-2006, Head, Division of Organic Chemistry (Synthesis), NCL, Pune 
     2006 - October 2017, Professor and Director, IISER Pune
     November 2017 - Present: Professor and Director, IISER Tirupati

Award and Honors

1985: Science Academy Medal for Young Scientists, Indian National Science Academy, New Delhi.
1993: Fellow, Indian Academy of Sciences, Bangalore
1998: CSIR Bhatnagar Award in Chemical Sciences
1999: Fellow, Indian National Science Academy, Delhi
2004: Silver Medal, Chemical Research Society of India, Bangalore
2005: TWAS Prize in Chemical Sciences
2005: Elected Secretary, Biomolecular Chemistry Division, Sub Committee, IUPAC
2006: JC Bose Fellowship, Department of Science and Technology, India
2006: Fellow, Academy of Sciences for Developing World (TWAS), Trieste
2014: SASTRA CNR Rao Award in Chemistry
2015: HK Firodia Award in Chemical Sciences
2016: National Researcher Award in Nanoscience and Technology, DST, New Delhi


Research interests
     
Biomolecular chemistry of nucleic acids, peptides and lipids; drug development; antisense/antigene technology; DNA diagnostics and nanotechnology; chemistry education

Recent Publications

1. Mahesh V. Sonar and Krishna N. Ganesh, Switching structures by H-bond rearrangement: Transformation of ß-structure in poly-4S-Aminoproline to PPII conformation, Org. Lett, 2010, 12, 5406-5409.

2. Roopa Mitra and Krishna Ganesh, PNAs grafted with (a/g, R/S)-aminomethylene pendants: Regio- and stereospecific effects on DNA binding and improved cell uptake, Chem. Commun., 2010, 12, 5390-5393.

3. Amit N. Patwa, Rajesh G. Gonnade, Vaijayanti A. Kumar, Mohan M. Bhadbhade, Krishna N. Ganesh, Ferrocene–bis(thymine/uracil) conjugates: Base pairing directed, spacer dependent self assembly and supramolecular packing, J. Org. Chem, 2010, 75, 8705-8708.

4. Nagendra K. Sharma and Krishna N. Ganesh, Enhanced stability of G-Tetraplexes from Conformationally Constrained aep-PNA backbone, Organic Biomolecular Chemistry, 2011, 9, 725-729.

5. A Gourishankar and Krishna N Ganesh (a,a-dimethyl)glycyl (dmg) PNAs: achiral PNA analogs that form stronger hybrids with cDNA relative to isosequential RNA, Art DNA, PNA:XNA, 2012, 3, 1-9.

6. M. Umashankara, Manaswini Nanda, Mahesh Sonar, and Krishna N. Ganesh, 4(R/S)-Amino/Guanidino-substituted Proline Peptides: Design, Synthesis and DNA Transfection Properties, Chimia, 2012, 66, 936–940.

7. Manaswini Nanda and Krishna N. Ganesh, 4(R/S)-Guanidinylprolyl Collagen Peptides: On-Resin Synthesis, Complexation with Plasmid DNA, and the Role of Peptides in Enhancement of Transfection, J. Org. Chem. 2012, 77, 4131-4135.

8. Krishna N Ganesh and Yamuna Krishnan, Nucleic Acids - Chemistry and Applications. J. Org. Chem. 2013, 78, 12283-12287.

9. Deepak R. Jain and Krishna N. Ganesh, Clickable C?-Azido(methylene/butylene) Peptide Nucleic Acids and Their Clicked Fluorescent Derivatives: Synthesis, DNA Hybridization Properties, and Cell Penetration Studies. J. Org. Chem. 2014, 79, 6708-6714.

10. Deepak Ramesh Jain, Libi Anandi V., Mayurika Lahiri, and Krishna N. Ganesh, Influence of Pendant Chiral C#-(alkylideneamino/guanidino) Cationic Sidechains of PNA Backbone on Hybridization with Complementary DNA/RNA and Cell Permeability, J. Org. Chem. 2014, 79, 9567-9577.

11. Deepak R. Jain and Krishna N. Ganesh, Clickable C?-Azido(methylene/butylene) Peptide Nucleic Acids and Their Clicked Fluorescent Derivatives: Synthesis, DNA Hybridization Properties, and Cell Penetration Studies. J. Org. Chem. 2014, 79, 6708-6714.

12. Deepak Ramesh Jain, Libi Anandi V., Mayurika Lahiri, and Krishna N. Ganesh, Influence of Pendant Chiral C?-(alkylideneamino/guanidino) Cationic Sidechains of PNA Backbone on Hybridization with Complementary DNA/RNA and Cell Permeability, J. Org. Chem. 2014, 79, 9567-9577.

13. Muddegowda Umashankara, Mahesh V. Sonar, Nitin D. Bansode and Krishna N. Ganesh, Orchestration of Structural, Stereoelectronic, and Hydrogen-Bonding Effects in Stabilizing Triplexes from Engineered Chimeric Collagen Peptides (ProX- ProY- Gly)6 Incorporating 4(R/S)-Aminoproline, J. Org. Chem. 2015, 80, 8552-8560.

14. Satheesh Ellipilli and Krishna N. Ganesh, Fluorous Peptide Nucleic Acids: PNA Analogues with Fluorine in Backbone (?-CF2-apg-PNA) Enhance Cellular Uptake, J. Org. Chem. 2015, 80, 9185-9191.

15. Satheesh Ellipilli, Raghavendra Vasudeva Murthy and Krishna N. Ganesh, Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size, Chem Commun, 2016, 52, 521-524.

16. Nitin D. Bansode, Mahesh V. Sonar and Krishna N. Ganesh, A nanofiber assembly directed by the non-classical antiparallel ß-structure from 4S-(OH) proline polypeptide, Chem. Commun., 2016, DOI: 10.1039/c6cc00838k

Patents

1. An enzymatic process for the preparation of optically pure diols, S.B.desai, N.P.Argade and K.N.Ganesh, Indian Patent, 2738/DEL/96

2. A new process for the preparation of (±)–threo-ethyl 3-(4-methoxyphenyl)-2,3-diacetoxy propionate, S. B. Desai, N.P. Argade and K. N. Ganesh, Indian Patent, 2739/DEL/96

3. Method for the hydrophobisation of DNA molecules, M. Sastry, A. Kumar, V. Ramakrishnan and K.N.Ganesh, U.S.Patent NF 304/01

4. Chiral, charged peptide nucleic acid oligomers from cyclic monomers, V. A. Kumar, M. D’Costa and K. N. Ganesh, US patent 7579563, (2009)